Providing expertise in prefillable syringe (PFS) technology you can trust

Biologics requiring high viscosity and high volume formulations continue to grow significantly in the market1. The BD Neopak™ Glass Prefillable Syringe platform has been designed to target these rapidly evolving needs. Discover the difference of our prefillable syringe technology!

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Pellentesque habitant morbi tristique senectus et netus et malesuada fames ac turpis egestas vestibulum tortor quam.


Pellentesque habitant morbi tristique senectus et netus et malesuada fames ac turpis egestas vestibulum tortor quam.

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Due to its high viscosity, injecting hyaluronic acid puts a lot of pressure on a syringe. That’s why hyaluronic acid manufacturers prioritize needle connection and LLA rotation issues that cause leakage.3 Our BD Hylok Syringe has:

  • A robust LLA design that reduces the risk of rotation1,2, allowing users to tightly screw on the needle.
  • A demonstrated record of excellent performance after terminal steam sterilization over time.1+

Discover more about our BD Hylok™ Syringe and our entire family of injectable delivery systems >

+ terminal steam sterilization at 121°C / 2 cycles / 20min

Due to its high viscosity, injecting hyaluronic acid puts a lot of pressure on a syringe. That’s why hyaluronic acid manufacturers prioritize needle connection and LLA rotation issues that cause leakage.3 Our BD Hylok Syringe has:

  • A robust LLA design that reduces the risk of rotation1,2, allowing users to tightly screw on the needle.
  • A demonstrated record of excellent performance after terminal steam sterilization over time.1+

Discover more about our BD Hylok™ Syringe and our entire family of injectable delivery systems >

+ terminal steam sterilization at 121°C / 2 cycles / 20min

Due to its high viscosity, injecting hyaluronic acid puts a lot of pressure on a syringe. That’s why hyaluronic acid manufacturers prioritize needle connection and LLA rotation issues that cause leakage.3 Our BD Hylok Syringe has:

  • A robust LLA design that reduces the risk of rotation1,2, allowing users to tightly screw on the needle.
  • A demonstrated record of excellent performance after terminal steam sterilization over time.1+

Discover more about our BD Hylok™ Syringe and our entire family of injectable delivery systems >

+ terminal steam sterilization at 121°C / 2 cycles / 20min

360° rotation knob is effectively sized, contoured and located to enable easy instrument rotation.

360° rotation knob is effectively sized

360° rotation knob is effectively sized

360° rotation knob is effectively sized


Engineered for superior performance with hyaluronic acid

Did you know that 72% of decision makers prefer glass syringes over plastic? Explore the benefits of the BD Hylok™ Glass Syringe and other unique features.3

BD Hylok™ Glass Prefillable Syringe for hyaluronic acid

Screw on tip cap
Easy to use and intuitive tip cap with proven user preference2

New bonding technology
Reduced risk of LLA disconnection/rotation1,2

New LLA thread design
Safe and robust needle connection4

Glass barrel
Limited risks and costs associated with potential container change

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Providing expertise in prefillable syringe (PFS) technology you can trust

Biologics requiring high viscosity and high volume formulations continue to grow significantly in the market1. The BD Neopak™ Glass Prefillable Syringe platform has been designed to target these rapidly evolving needs.

Discover the difference of our prefillable syringe technology!

Committed to drug delivery

Discover the BD Neopak™ Glass Prefillable Syringe platform with tailorable medication delivery solution that can help support the development of your biologic drug.

Getting your drug to market with a solution focused on patient safety and usability

Advanced needle technology for an improved patient experience

Available in both 1mlL and 2.25 ml configurations, the BD Neopak™ XtraFlow™ Glass Prefillable Syringes* are specially designed to enhance the patient experience when administering high viscosity / high volume drugs.2,3 With a shorter 8 mm needle and thinner wall cannula technology, these syringes may help reduce the risk of intramuscular injection.2 Benefits include:

  • Decreased injection force and/or time at a fixed solution viscosity3
  • Lessened intramuscular injection risk by 2.5 to 12.6 times2,**
  • Reduced needle related anxiety2
  • Positive impact on patient acceptance2,§


*Currently under development.
**Extrapolation from the mathematical model developed by Gibney and colleagues (2010)
§ Patient acceptance rate was evaluated and compared between 8mm and 12.7mm needle, with a 10cP solution.

Resources

 
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Article - Improving subcutaneous biologic drug delivery
 
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Article - How shorter needles with thinner walls are set to improve the injection experience
 

Focused on the patient experience

Since 2010, we have conducted more than 80 human factor studies15 to ensure the usability of our drug delivery solutions. Our diverse portfolio features integrated devices and systems that can deliver biologics across a wide range of volume and viscosity levels to help treat chronic conditions.

Access chronic solutions presentation >
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REFERENCES

1. World Preview 2018, Outlook to 2024. Evaluate Pharma, 2018
2. User experience for manual injection of 2 mL viscous solutions is enhanced by a new prefillable syringe with a stacked 8 mm ultra-thin wall needle, Expert Opinion on Drug Delivery, Pager 2020
3. Injection time and ejection force calculation, BD internal study, 2020
4. Flora F. et al., 2012. Silicone-Oil-Based Subvisible Particles: Their Detection, Interactions, and Regulation in Prefilled Container Closure Systems for Biopharmaceuticals, 2012
5. Depazet al. Cross-Linked Silicone Coating: A Novel Prefilled Syringe Technology That Reduces Subvisible Particles and Maintains Compatibility with Biologics. JOURNAL OF PHARMACEUTICAL SCIENCES 103:1384–1393, 2014
6. BD Neopak™ XSi™ 1mlL-Competitive Benchmark [Internal Study]. Pont-de-Claix, FR: Becton Dickinson and Company; 2020
7. BD Neopak™ XSi™ 2.25ml 27G STW ½’’ - Empty AGF. [internal Study].Pont-de-Claix, FR: Becton Dickinson and Company. 2019
8. BD Neoak™ XSi™ 2.25ml 27G STW ½’’ - injection time. [internal Study]. Pont-de-Claix, FR: Becton Dickinson and Company. 2019
9. Practical considerations in clinical strategy to support the development of injectable drug device combination product for biologics. 2018
10. Assembly and handling of UltraSafe Passive Devices for Assembly machine supplier, BD, 2017
11. Assembly and handling of UltraSafe PLUS Passive Devices for Assembly machine supplier, BD, 2018
12. BD Intevia 2.25mL and glass pre-fillable syringe delivery systems, BD DIS, 2018
13. STMT-QE20192089 Post market surveillance Physioject, BD, 2019
14. PMS20212355 Physioject PMS report, BD, 2021
15. BD-PS list of human factor studies, BD, 2020

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